The Future Of Hiv 1 Therapeutics

The Future Of Hiv 1 Therapeutics

The Future Of Hiv 1 Therapeutics

This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.

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Product Details:

Genre : Medical
Author : Bruce E. Torbett
Publisher : Springer
Release : 2015-04-22
Total Pages : 254 Pages
ISBN : 9783319185187


Hiv 1 Latency

Hiv 1 Latency

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

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Product Details:

Genre : Medical
Author : Guido Silvestri
Publisher : Springer
Release : 2018-10-11
Total Pages : 248 Pages
ISBN : 9783030028169


Hiv 1 Integrase

Hiv 1 Integrase

This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.

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Product Details:

Genre : Science
Author : Nouri Neamati
Publisher : John Wiley & Sons
Release : 2011-08-10
Total Pages : 520 Pages
ISBN : 9781118015360


Disease Control Priorities In Developing Countries

Disease Control Priorities In Developing Countries

Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.

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Product Details:

Genre : Medical
Author : Dean T. Jamison
Publisher : World Bank Publications
Release : 2006-04-02
Total Pages : 1452 Pages
ISBN : 9780821361801


Aids And Other Manifestations Of Hiv Infection

Aids And Other Manifestations Of Hiv Infection

Provides an update on AIDS and other HIV infections. Over 40 chapters present information on the biological properties of the etiologic viral agent, its clinico-pathological manifestations, the epidemiology of HIV infection and the day-to-day management of HIV infected patients.

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Product Details:

Genre : Medical
Author : Gary P. Wormser
Publisher : Raven Press (ID)
Release : 1992
Total Pages : 715 Pages
ISBN : UOM:39015021553774


Antiretroviral Resistance In Clinical Practice

Antiretroviral Resistance In Clinical Practice

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Genre :
Author :
Publisher :
Release : 2006
Total Pages : 200 Pages
ISBN : OCLC:1016468897


Combination Therapy Of Aids

Combination Therapy Of Aids

An extensive assessment of combination therapy of AIDS. Main focus is put on the Highly Active Antiretroviral Therapy (HAART) but other therapies like salvage therapy are also discussed. The chapters cover efficacy, treatment, causes of treatment failure, clinical care, guidelines, pharmacology. The volume closes with an outlook on future perspectives.

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Product Details:

Genre : Medical
Author : Erik De Clercq
Publisher : Birkhäuser
Release : 2012-12-06
Total Pages : 243 Pages
ISBN : 9783034878692


Exploring Novel Approaches To Eliminate Hiv Reservoirs To Achieve A Cure For Hiv

Exploring Novel Approaches To Eliminate Hiv Reservoirs To Achieve A Cure For Hiv

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Product Details:

Genre : Science
Author : Renee Marije Van Der Sluis
Publisher : Frontiers Media SA
Release : 2021-04-07
Total Pages : Pages
ISBN : 9782889666669


Anti Hiv Nucleosides

Anti Hiv Nucleosides

In 1985, a broad family of dideoxynucleoside reverse transcriptase inhibitors were identified as being active against a divergent range of HIV "in vitro." Three such drugs - AZT, ddC, and ddI - had become prescription drugs by 1991. More recently, d4T and 3TC have been added to this nucleoside armamentarium. Indeed, despite their side effects, insufficient antiviral activity, and the propensity of HIV-1 to develop drug resistance, anti-HIV nucleosides have brought about substantial clinical benefits to HIV-1-infected individuals in the last decade. Even with the development of new modalities of AIDS therapy, anti-HIV nucleosides will continue to play a major role in the therapy of HIV-1 infection. This book discusses the development, rationale, present status, and the future of the use of anti-HIV nucleosides.

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Product Details:

Genre : AIDS (Disease)
Author : Hiroaki Mitsuya
Publisher :
Release : 1997-01-01
Total Pages : 178 Pages
ISBN : 354061950X


Reverse Transcriptase Inhibitors In Hiv Aids Therapy

Reverse Transcriptase Inhibitors In Hiv Aids Therapy

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.

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Product Details:

Genre : Medical
Author : Gail Skowron
Publisher : Springer Science & Business Media
Release : 2007-11-10
Total Pages : 528 Pages
ISBN : 9781597450850